
A few more developments on 'fat', building on my earlier post on the topic:
* The BBC have just reported on a rat-based study from the Royal Veterinary College, suggesting that junk-food eating, pregnant mothers may be predisposing their children to a preference for similar unhealthy food:
The female rats used in the Wellcome Trust funded research were either given a balanced diet of "rat chow" - an unappealing but reasonably healthy diet - or access to as many doughnuts, biscuits, muffins, sweets and crisps as they could consume.
This diet was continued in some rats up to birth, and then during the breastfeeding period until weaning.
Unsurprisingly, the rats given free rein to eat sweets consumed more food overall.
Significantly, however, their babies showed marked differences in behaviour compared with the offspring of chow-fed rats.
The young rats were split into different groups - some of those from chow-fed mothers given nothing but their chow to eat, while the babies of junk-fed mothers, and the rest from chow-fed mothers, were given a mixture of chow and junk food to see which they chose.
Those in the chow-only group consumed the least food, while those from healthy-eating mothers given junk food again were tempted to eat more.
They ate roughly twice as much as those on the chow-only diets.
The researchers suggested that the "pleasure chemicals" released by the mother when eating fatty foods might have an effect on the developing brain of the foetus.
While we can't draw any firm conclusions about what this means for humans, I wouldn't be at all surprised if evidence eventually comes out supporting this idea about 'foetal programming' with respect to one's diet. For sure, it is easy to construct an evolutionary based theory as to why such pre-programming would be beneficial for offspring. The notion also seems to fit very well with epigentics, which I discussed earlier. Indeed, my first article on epigentics concluded with, 'So, next time you stuff yourself with donuts, liquor, drugs, or whatever else your poison may be, bear in mind that somewhere inside your body, these little (biochemical) switches may be clicking on and off !'. In the same piece, as an aside, I commented that 'I haven’t looked in to it yet, but I have hypothesized for a long time that the while the prevalence of diabetes among Indian’s can be attributed to to diet, the higher risk of of diabetes in the next generation (who eat a more Western diet) can be atrributed in part to hereditary factors. I may be reaching here, but epigenetics would provide the perfect bridge.' Well, the press release from the Royal Veterinary College reports that:
The study published in The Journal of Physiology carried out by Professor Neil Stickland and Dr Stephanie Bayol showed that rats fed doughnuts, muffins, chocolate, crisps, cheese, biscuits and sweets during pregnancy and lactation gave birth to offspring which showed increased fatness and muscle waste. The offspring also showed signs of insulin resistance, a condition that precedes the early onset of type-2 diabetes, as early as 3 weeks of age.
*
The dangerous pot belly - The
BBC has another story telling us that all not fat is not equal. Reporting on
study from the University of Texas, a strong link was found between having an apple shaped body (i.e, a pot-belly) and the risk of heart disease. Because of this, the BMI health measure may be less effective that a simple waist-to-hip ratio (WTR) measure. So, as well as keeping an eye on our total body weight, we also need to consider our body shape.
Quoting Professor James de Lemos, who led the research:
"Fat that accumulates around your waist seems to be more biologically active as it secretes inflammatory proteins that contribute to atherosclerotic plaque build-up, whereas fat around your hips doesn't appear to increase risk for cardiovascular disease at all.
"We think the key message for people is to prevent accumulation of central fat early on in their lives.
"Even a small pot belly puts us at higher risk when compared to a flat tummy."
While these findings may not be particularly ground breaking - I've come across such research before - they should help in getting people to think about body fat in a different way.